A novel mechanism for the control of growth factor activity

生长因子是一种分泌的信号分子，控制着细胞生长、增殖和死亡等基本生物过程。膜攻击复合体/穿孔素样蛋白(MACPF)控制生长因子的机制是非常新颖的，因为MACPF蛋白通常在脊椎动物的免疫反应中起到杀死病原体的作用。该项目旨在揭示MACPF类蛋白质躯干是如何利用果蝇中可能的复杂遗传和先进成像方法控制高度定位的生长因子信号的。该项目旨在了解生长因子控制，因为其放松管制会导致严重的发育障碍和疾病。

Growth factors are secreted signalling molecules that govern fundamental biological processes such as cell growth, proliferation and death. The mechanism for growth factor control by a Membrane Attack Complex/Perforin-like (MACPF) protein is highly novel as MACPF proteins typically function to kill pathogens during the vertebrate immune response. This project aims to reveal how the MACPF protein Torso-like controls highly localised growth factor signalling, using the sophisticated genetic and advanced imaging methods possible in the fruit fly Drosophila. This project aims to understand growth factor control as its deregulation leads to serious developmental disorders and diseases.