PERMEABILITY OF HYPERPLASTIC AND HYPERKERATOTIC ORAL EPITHELIUM

衬在口腔内的口腔粘膜代表限制口腔粘膜的屏障。 外源性物质进入下层组织。 测量 人体和实验动物组织的渗透性表明， 在不同的口腔区域之间存在相当大的差异。 等 变异可能解释了某些口腔区域对 疾病，其中外在病因，如烟草或酒精，是 涉案 由此产生的一个问题是， 如增生和角化过度，这是已知的， 与未改变的粘膜相比， 高渗透性地区。 这项研究的假设是， 任何与口腔粘膜表面接触的试剂必须首先 在它可以发挥作用之前穿透上皮的渗透屏障。 局部效应 具体的目的是确定是否渗透性 人类口腔粘膜在上皮改变区域发生改变，例如 增生和角化过度。 这项研究将涉及使用 使用特定放射性标记示踪剂测量渗透性的方法。 将修改程序，以允许使用小（4 mm直径） 人口腔粘膜的活组织检查。 结果将提供重要的 关于粘膜疾病病因的信息，并将允许 研究增加渗透性可能是 重要病因。

The oral mucosa lining the oral cavity represents a barrier that limits the access of exogenous material to the underlying tissues. Measurements of permeability of the tissue in man and experimental animals indicates that there is considerable variation between different oral regions. Such variation might explain the susceptibility of certain oral regions to disease, where an extrinsic etiology, such as tobacco or alcohol, is involved. A question that arises is whether common pathological conditions of the mucosa such as hyperplasia and hyperkeratosis, which are known to represent a higher risk of malignant disease than unaltered mucosa, are areas of high permeability. The hypotheses underlying the research is that any agent coming in contact with the surface of the oral mucosa must first penetrate the permeability barrier of the epithelium before it can exert a local effect. The specific aim is to determine whether the permeability of human oral mucosa is modified in areas of epithelial alteration, such a hyperplasia and hyperkeratosis. The research will involve the use of methods to measure permeability using specific radiolabeled tracers. Procedures will be modified to permit the use of small (4 mm diameter) biopsies of human oral mucosa. The outcomes will provide important information on the etiology of mucosal disease and will permit investigation of conditions in which increased permeability may be an important etiologic factor.