AGE EFFECTS ON BLOOD PRESSURE AND CIRCULATING SODIUM-PUMP INHIBITORS

流行病学研究表明，平均血压和 高血压患病率均随年龄增长而增加。一个可能的角色是 膳食钠摄入量对老年个体血压的影响 已经被记录在案，但几乎没有关于 影响钠的循环激素可能与年龄相关的变化 通过血管平滑肌运输。本研究评估 两种循环钠泵抑制水平的个体差异 激素作为静息血随年龄变化的预测因子 压力。早晨仰卧位血压和内源性哇巴因 巴尔的摩老龄化纵向研究中测量到地高辛样因子 符合纳入标准的参与者。该研究还调查了 循环钠泵抑制剂作为一种功能的可能差异 种族和性别。数据支持一个积极的假设 静息血压与循环钠泵的相关性研究 抑制剂可能导致药理学和非药理学 以钠泵抑制剂及其受体为重点的高血压干预 决定因素。

Epidemiological studies have shown that mean blood pressure and the prevalence of hypertension both increase with age. A possible role for dietary sodium intake in the blood pressure increase in aging individuals has been documented, but little information is available concerning possible age-associated changes in circulating hormones that affect sodium transport across vascular smooth muscle. The present study assesses individual differences in levels of two circulating sodium-pump inhibiting hormones as predictors of age-associated changes in resting blood pressure. Morning supine blood pressure and endogenous ouabain and digoxin-like factor are measured in Baltimore Longitudinal Study on Aging participants who meet the inclusion criteria. The study also investigates possible differences in circulating sodium-pump inhibitors as a function of race and gender. Data supporting the hypothesis of a positive correlation between resting blood pressure and circulating sodium-pump inhibitors could lead to pharmacological and nonpharmacological intervention in hypertension focusing on sodium-pump inhibitors and their determinants.