CNS CONSORTIUM--NEW APPROACHES TO BRAIN TUMOR THERAPY

该提案描述了哥伦比亚大学作为参与方的作用 财团中的机构，其主要长期目标是 提高原发性脑肿瘤患者的存活率。中环 神经系统联盟被命名为脑瘤治疗的新方法 (NABTT)，包括七个参与机构：布朗大学、 哥伦比亚大学，克利夫兰诊所，约翰霍普金斯大学， 马萨诸塞州总医院、西北大学和 宾夕法尼亚大学。NABTT联盟将开发和执行 前景看好的新药物的I期和II期临床评价 肿瘤治疗中的生物学途径和给药途径 患有原发中枢神经系统恶性肿瘤的成年人。财团成员还将 协作和共享肿瘤标本、临床数据、实验室数据和 对大脑的基本生物学进行额外研究的专业知识 肿瘤和改善患者的护理和生活质量 脑瘤。NABTT联盟将依靠约翰家的专业知识 霍普金斯大学作为财团总部并提供 组织支持、生物统计和数据分析、质量控制 并研究监控。哥伦比亚大学在世界范围内的作用 财团将于20日或20日执行财团批准的协议 每年有更多的脑瘤患者，参加组织 为该财团进行规划，并在其他相关大脑方面进行合作 肿瘤研究项目。这份提案描述了哥伦比亚大学的资源和 在神经肿瘤学方面的能力，这将促进其参与 这份有价值的合作协议。

This proposal describes the role of Columbia University as a Participating Institution in a consortium whose primary long-term objective is to improve the survival of patients with primary brain tumors. The Central Nervous System Consortium is titled New Approaches to Brain Tumor Therapy (NABTT) and includes seven participating institutions: Brown University, Columbia University, The Cleveland Clinic, The Johns Hopkins University, The Massachusetts General Hospital, Northwestern University and the University of Pennsylvania. The NABTT Consortium will develop and perform Phase I and Phase II clinical evaluations of promising new agents, novel biological approaches and routes of administration in the treatment of adults with primary CNS malignancies. The Consortium members will also collaborate and share tumor specimens, clinical data, laboratory data and expertise to conduct additional research into the basic biology of brain tumors and improving the care and quality of life of individuals with brain tumors. The NABTT Consortium will rely on the expertise of the Johns Hopkins University to serve as the Consortium Headquarters and to provide organizational support, biostatistical and data analysis, quality control and study monitoring. The function of Columbia University within the Consortium will be to conduct consortium-approved protocols on twenty or more brain tumor patients per year, to participate in organizational planning for the consortium and to collaborate on other related brain tumor research projects. This proposal describes Columbia's resources and capabilities in neur-oncology which will facilitate its participation in this worthwhile cooperative agreement.