Coordination of withdrawal from the cell cycle by transcriptional repression

癌症的特点是几个基本的细胞过程发生了变化，包括癌细胞无法响应身体正常的停止信号而停止生长。当细胞正常停止生长时，许多基因的活性就会发生深刻的变化。本提案旨在研究这些基因活性的变化是如何产生的。我们认为，最近发现的一个名为SWI-SNF的基因家族与另外两个基因家族（mad家族和rb家族）共同作用，导致细胞生长停止。如果我们的建议被证实，它将为评估人类癌症的生长特性开辟新的途径，并可能导致抑制细胞生长的新策略。

Cancer is characterised by changes in several fundamental cellular processes including the failure of the cancer cells to stop growing in response to the body's normal stop signals.. When cells normally stop growing there is profound changes in the activity of many genes. This proposal aims to investigate how these changes in gene activity are brought about. We propose that a recently discovered family of genes called SWI-SNF work with two other families of genes (the Mad-family and Rb-family) to bring about the cessation of cell growth. If our proposal is proven it will open new avenues to evaluate the growth properties of human cancers and may lead to novel strategies to inhibit cell growth.