MUCIN GENE EXPRESSION AND MEDIATORS OF INFLAMMATION IN CLINICAL SPECIMENS

过多的呼吸道分泌物与多种 炎症性气道疾病。该项目的目的是 表征气道上皮细胞中的基因表达， 正常受试者和受试者气道中的炎性细胞 哮喘或慢性支气管炎受试者的研究历史 以及体格检查、胸部X光检查和肺功能检查。 如果随后进行支气管镜检查， 其中进行支气管灌洗和粘膜活组织检查。到目前为止， 研究了七个主题。其中包括4名正常受试者， 3例哮喘受试者。受试者招募目前正在进行中。是 希望这项研究有助于了解 哮喘和慢性支气管炎气道炎症的性质， 了解气道上皮细胞对 炎症刺激和气道上皮细胞的理解 炎症反应的细胞调节。这些研究应 允许增加对上皮细胞反应的理解 气道炎症

Excessive respiratory secretions are associated with a variety of inflammatory airway diseases. The purpose of this project is to characterize the gene expression in airway epithelial cells and in inflammatory cells in the airway in normal subjects and in subjects with asthma or chronic bronchitis. Subjects are studied with a history and physical examination, chest X-ray, and pulmonary function tests. This screening evaluation if followed by a bronchoscopic examination in which bronchial lavage and mucosal biopsies are taken. To date, seven subjects have been studied. These include 4 normal subjects and 3 asthmatic subjects. Subject accrual is currently ongoing. It is hoped that this study will contribute to the understanding of the nature of airway inflammation in asthma and chronic bronchitis and to the understanding of the airway epithelial cell response to inflammatory stimuli and to the understanding of airway epithelial cell modulation of the inflammatory response. These studies should allow for increased understanding of epithelial cell responses to airway inflammation.