MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

此应用程序请求继续支持多功能关节炎 中心（MAC）在圣地亚哥，加州。 合作的研究人员在 该中心以前设在斯克里普斯诊所和研究 基金会和圣地亚哥州立大学，在博士的董事。 工程硕士Tan. 谭博士现已将中心主任一职移交给 博士Dennis A.卡森，研究部门的主任。 自从博士。 卡森和罗伯特卡普兰博士，卫生服务和 教育部分，已接受大学教师的任命 的加州，圣地亚哥（UCSD），MAC现在将设在这个网站。 新的中心将大大扩大设施，并将包括 加州大学圣地亚哥分校医学院流变学部的参与， 数学和生物统计学系，以及 社区和家庭医学。 MAC分为三个部分：（1） 核心;（2）研究部分;（3）卫生服务， 教育部分。 核心提供必要的服务，以确保 该中心的研究、卫生服务和教育部门， 此外，促进参与教师之间的互动。 国债风险不但包括 （1）执行委员会，负责科学 中心的方向，（2）一个行政核心，将计划， 发展和协调中心正在进行的活动，（3）a 临床核心，将招募和评估患者，并将获得 个体研究者的临床样本，（4）分子生物学核心 其将作为寡核苷酸合成、载体 准备和基本分子生物学技术培训，以及（5）a 生物统计学核心，将有助于设计，分析和评价 实验方案。 研究部分包括六个独立的项目：（1）生物化学 一种新的抗单核细胞/巨噬细胞作用的免疫学分析 类风湿性关节炎患者中的药物（2-氯脱氧腺苷），（2） SS-B/La自身表位的功能和分子分析 自身抗原，（3）滑膜组织中细胞因子表达的分析 从类风湿性关节炎患者，使用原位杂交，（4） 一种新的全身性自身免疫动物模型的详细评价 （5）剖析了氯化汞诱发的细胞凋亡机制， HLA Dw 4抗原影响对EB病毒的免疫应答 病毒的分子生物学分析，以及（6）抗- 碳水化合物抗体和自身抗体。 卫生服务和教育部分包括四个独立的 项目：（1）对未来预测因素的调查 一个大型中产阶级退休社区的肌肉骨骼问题， 圣地亚哥地区，（2）肌肉骨骼的影响分析 卫生政策的问题，（3）行为的好处的试验 纤维组织炎综合征患者的干预措施，和（4）一项研究， 习得性无助与甲氨蝶呤疗效关系 类风湿性关节炎的患者。 新的MAC包括具有基本经验和专业知识的个人， 研究、卫生服务研究和医学教育。 通过 在该中心的主持下，这些人将相互作用，以促进关节炎 研究，培训和教育在不断增长的圣地亚哥社区。

This application requests continued support for the Multipurpose Arthritis Center (MAC) in San Diego, California. The collaborating investigators in the Center were previously based at the Scripps Clinic and Research Foundation and at San Diego State University, under the directorship of Dr. Eng M. Tan. Dr. Tan has now transferred the directorship of the Center to Dr. Dennis A. Carson, the director of the Research Component. Since Dr. Carson, and Dr. Robert Kaplan, the director of the Health Services and Education Component, have accepted faculty appointments at the University of California, San Diego (UCSD), the MAC will now be based at this site. The new Center will have greatly expanded facilities, and will include the participation of the Rheumatology Division at the UCSD School of Medicine, the Department of Mathematics and Biostatistics, and the Department of Community and Family Medicine. The MAC is divided into three parts: (1) the Cores; (2) the Research Component; and (3) the Health Services and Education Component. The Cores provide services necessary for the proper functioning of the Research and Health Services and Education components of the Center, and in addition foster interactions among the participating faculty. They consist of (1) an Executive Committee that will be responsible for the scientific direction of the center, (2) an Administrative Core that will plan, develop, and coordinate the ongoing activities of the center, (3) a Clinical core that will recruit and evaluate patients, and that will obtain clinical samples for individual investigators, (4) a Molecular Biology Core that will serve as a shared resource for oligonucleotide synthesis, vector preparation, and training in basic molecular biology techniques, and (5) a Biostatistics Core that will assist in the design, analysis, and evaluation of experimental protocols. The Research Component contains six separate projects: (1) a biochemical and immunologic analysis of the effects of a new anti-monocyte/macrophage agent (2-chlorodeoxyadenosine) in patients with rheumatoid arthritis, (2) a functional and molecular analysis of the autoepitopes on the SS-B/La autoantigen, (3) an analysis of cytokine expression in the synovial tissues from patients with rheumatoid arthritis, using in situ hybridization, (4) a detailed evaluation of a new animal model of systemic autoimmunity induced by mercuric chloride, (5) a dissection of the mechanism by which the HLA Dw4 antigen influences the immune response to the Epstein-Barr virus, and (6) a molecular analysis of the relationship between anti- carbohydrate antibodies and autoantibodies in humans. The Health Services and Education Component contains four separate projects: (1) an investigation of prospective predictors of musculoskeletal problems in a large middle-class retirement community in the San Diego area, (2) an analysis of the impact of musculoskeletal problems on health policy, (3) a trial of the benefits of behavioral interventions for patients with the fibrositis syndrome, and (4) a study of the relationship between learned helplessness and response to methotrexate in patients with rheumatoid arthritis. The new MAC includes individuals with experience and expertise in basic research, health services research, and medical education. Through the auspices of the Center, these individuals will interact to foster arthritis research, training, and education in the growing San Diego community.