MASS SPECTROMETRY

此修订后的申请描述了一个有效和经济的计划， 我们新重组的质谱分析设备 BRTP的使命 一名中央工作人员将提供技术支持， 仪器的操作和维护，培训， 数据，并监督参与技术研究的研究人员 研究和发展项目，涉及开发 MALDL离子结构分析的化学和仪器方法 生物聚合物的分析。 研究助理也将服务于 作为我们用户社区之间的互动联络人， 基金的共同研究者和PI的资助研究项目。 这一建议与几个独立关联的积极互动 获得资助的项目将丰富用户可用的技术基础， 帮助确保TRD的工作针对用户的需要 的设施。 与大分子结构的相互作用（肽） 位于质谱分析设施附近的设施将 继续加强每个设施的专业知识和能力， 为用户服务。 质谱设施有九台质谱仪，其中五台 主要致力于80多个国家的利益 生物医学研究人员在当地，区域和国家科学 社区 质谱分析设备是一所共享的大学 管理支助股的设施协助购置了主要设备 鼓励创新研究活动，并提供一个国家的- 校园内最先进的仪器和研究基地。 培训继续 是质谱分析设备的主要活动， 约20位博士研究生正在进行研究， PI和合作研究者的指导。 然而，没有金融 支持在这个应用程序中要求研究生。 支持 要求三名研究助理谁将获得高级 在质谱方面的培训，谁，沿着与PI和合作， 研究人员将在质谱设施中进行TRD。 通过学术机构， 在MSU的计划，以及通过一个短期的形式推广计划， 课程由美国化学学会赞助，既作为校外 仅讲座版本，并作为一个为期五天的校园“动手”计划。

This revised application describes an efficient and economical plan for our newly reorganized Mass Spectrometry Facility to serve the five missions of BRTP. A central staff will provide technical support for operation and maintenance of instruments, training, interpretation of data, and supervision of research associates involved in Technological Research and Development (TRD) projects involving the development of chemical and instrumental approaches to structure analysis of MALDL ions in the analysis of biopolymers. The research associates also will serve as interactive liaisons between our user community and independently- funded research projects of the Facility's co-investigators and PIs. This proposed active interaction with several associated independently funded projects will enrich the technology base available to users and help ensure that efforts in TRD are directed toward the needed of users of the Facility. Interaction with the Macromolecular Structure (Peptide) Facility, located adjacent to the Mass Spectrometry Facility, will continue to enhance the expertise and capabilities of each facility in serving its users. The Mass Spectrometry Facility houses nine mass spectrometers, five of which are dedicated principally to the interests of more than 80 biomedical investigators in the local, regional, and national scientific community. The Mass Spectrometry Facility is a shared University Facility in that MSU has assisted in the acquisition of major equipment to stimulate innovative research activities and to provide a state-of- the-art instrumentation and research base on campus. Training continues to be a major activity of the Mass Spectrometry Facility where approximately 20 Ph.D. graduate students are conducting research under the direction of the PIs and co-investigators. However, no financial support is requested in this application for graduate students. Support is requested for three research associates who will obtain advanced training in mass spectrometry and who, along with the PIs and co- investigators, will conduct TRD in the Mass Spectrometry Facility. Formal training in mass spectrometry is available through academic programs at MSU as well as via an outreach program in the form of a Short Course sponsored by the American Chemical Society both as an off-campus lecture-only version and as a five-day on-campus "hands-on" program.