DEVELOP AND MAINTAIN A CRYOPRESERVED EMBRYO BANK

本合同的目的是建立和维护一个冷冻保存的 基因定义的实验大鼠和小鼠的胚胎库 老年大鼠和小鼠的NIA克隆，可用于重建 任何特定的菌株都应该是基因污染或偏差 在重新衍生NIA菌落后检测到，或疾病或 环境灾难时有发生。同样，调查人员的结果是否应该 在一个或多个重新派生后开始偏离其过去的标准 如果发生这种情况，这个种群中的胚胎将被用来尝试并确定 所看到的影响的演变来自动物或研究人员。之前 停止动物进入目前三个国家中的每一个 已建立的NIA老化啮齿动物群体、繁殖者雄性和雌性或 怀孕的女性基金会股票将被送到承包商进行 扩大以产生足够数量的潜在胚胎捐赠者。

The purpose of this contract is to establish and maintain a cryopreserved embryo bank of genetically defined laboratory rats and mice derived from the NIA colonies of aged rats and mice, which can be used to re-establish any particular strain should a genetic contamination or deviation be detected after rederivation of the NIA colonies, or a disease or environmental disaster occur. Similarly, should an investigator's results start deviating from their past norm after one or more rederivations have occurred, embryos from this stock would be used to try and determine if the evolution of effects seen was of animal or investigator origin. Prior to the cessation of entry of animals into each of the three currently established NIA aging rodent colonies, breeder males and females or pregnant female foundation stock will be sent to the Contractor for expansion to yield sufficient number of potential embryo donors.