THEORETICAL INVESTIGATIONS OF GENETIC IDENTITY AND DISEQUILIBRIA

我们的研究集中在通过以下途径定位基因的可行性 连锁不平衡。连锁不平衡表现在 种群水平，因此与通过以下方式定位基因相比具有一定优势 系谱分析。特别是，我们希望这一战略能够 用于定位表型至少部分依赖于非表型的基因 遗传因素，如接触病毒或毒素。总体而言, 连锁不平衡将只存在于物理上 彼此非常接近，所以我们需要确定种群的类型 这可能显示出基因之间的连锁不平衡 联系松散。满足这一要求的两种类型的人群是 (1)最近遇到瓶颈或创始人事件的人群 进化史和(2)具有最近历史的种群 种族混杂。前一类人口可能不那么普遍，或者 在理论上是有用的；例如，如果 总体遗传可变性。因此，我们集中讨论了 种族混杂群体中基因定位的评价。我们的 到目前为止，调查的目的是识别和评估所有 预计在进行地图研究时会遇到的相关参数 这一类。此外，我们的工作重点是识别和 评价用于识别这种联系的战略或标准 存在于一对基因之间。

Our research has focussed on the feasibility of mapping genes through linkage disequilibrium. Linkage disequilibrium is manifested at the population level and thus has certain advantages over mapping genes by pedigree analysis. In particular, it is our hope that this strategy can be used to map genes whose phenotype depends, at least in part, on non- genetic factors such as exposure to viruses or toxins. In general, linkage disequilibrium will only exist between genes that are physically very close to each other, so we needed to identify types of populations that might show linkage disequilibrium between genes that are relatively loosely linked. Two types of populations that meet this requirement are (1) populations that have a recent bottleneck or founder event in their evolutionary history and (2) populations that have a recent history of racial admixture. The former type of population might be less general or useful on theoretical grounds; for instance, if there is a reduction in overall genetic variability. We have therefore concentrated on the evaluation of mapping genes in racially admixed populations. Our investigations thus far have been designed to identify and evaluate all of the relevant parameters expected to be encountered in a mapping study of this sort. Additionally, our work has focussed on identification and evaluation of the strategies or criteria used for discerning that linkage exists between a pair of genes.