RENAL LESIONS IN THE ABLATION MODEL

大鼠肾大部切除，5/6的消融模型，导致 进行性肾功能丧失和慢性肾功能衰竭。我们 推测进行性肾小球病变是由于早期 肾小球驻留细胞周转率增加。这导致了 肾小球异常生长，肾小球体积增大 这是可以通过形态测量检测的。我们已经表演了 用~3H-胸腺嘧啶核苷进行放射自显影研究，发现在两个 肾大部切除术后数天，肾小球数增加 肾小球细胞有丝分裂指数，以及肾小球细胞周转率的增加 动脉壁中的细胞。这些发现表明，监管失调 细胞生长受阻是肾小球硬化发展的早期事件 随着肾脏重量的减少。

Subtotal nephrectomy in rats, the 5/6ths ablation model, leads to progressive loss of kidney function and chronic renal failure. We postulated that the progressive glomerular lesions were due to an early increase in the turnover of glomerular resident cells. This leads to abnormal glomerular growth, with an increase in the glomerular volume which was detectable using morphometric measurements. We have performed autoradiographic studies, using 3H-thymidine, and found that within two days following subtotal nephrectomy there was an increase in the glomerular cell mitotic index, as well as an increase in the turnover of the cells in the arterial wall. These findings suggest that dysregulation of cell growth is an early event in the development of glomerulosclerosis following reduction in renal mass.