MOUSE MUTANT GENE RESOURCE

小鼠突变基因资源（MMGR）的长期目标 杰克逊实验室是提供一个新的自发的持续来源， 用于生物和生物医学研究的突变。 自发突变 是人类条件模型的主要来源， 突变的基因还没有被克隆。 的具体目标 MMGR程序是（1）鉴定小鼠中的新突变;（2） 描述新突变体的遗传、表型特征， （3）建立新的突变菌株， 我们和其他人的进一步分析;（4）将它们作为冷冻胚胎保存 以确保它们的持续可用性，以及（5）提供突变体， 控制其他调查人员。 新的突变将被识别 从杰克逊实验室的 繁殖殖民地 它们的基因特征是 遗传模式，测试与任何已知的等位基因 产生相似表型的突变，并确定 染色体定位 新的变种人将被描述为 通过观察它们的生育力、生长、生存能力、寿命 跨度，和行为，并通过定义他们的解剖，组织病理学， 和生理异常 新的突变体有可能 生物医学研究将被保留，作为冷冻胚胎保存， 在公开文献中描述，并提供给其他 杰克逊实验室和世界范围内的科学研究人员 社区

The long range goal of the Mouse Mutant Gene Resource (MMGR) at The Jackson Laboratory is to provide a continuing source of new spontaneous mutations for biological and biomedical research. Spontaneous mutations in the mouse are the primary source of models for human conditions for which the mutated gene has not been cloned. The specific objectives of the MMGR program are to (1) identify new mutations in the mouse; (2) characterize the new mutants genetically, phenotypically, and pathologically; (3) establish the new mutations in strains suitable for further analysis by us and others; (4) preserve them as frozen embryos to assure their continued availability, and (5) provide mutants and controls to other investigators. The new mutations will be identified from among phenotypic deviants appearing in The Jackson Laboratory's breeding colonies. They will be characterized genetically by determining the mode of inheritance, testing for allelism with any already known mutations that produce similar phenotypes, and determining the chromosomal location. The new mutants will be characterized pheonotypically by observing their fertility, growth, viability, life span, and behavior and by defining their anatomical, histopathological, and physiological abnormalities. New mutants with potential for biomedical research will be maintained, preserved as frozen embryos, described in the open literature, and made available to other investigators at The Jackson Laboratory and in the world-wide scientific community.