ENTEROTOXIGENIC E. COLI SEROEPIDEMIOLOGY EVALUATIONS IN ALEXANDRIA, EGYPT

产肠毒素大肠杆菌(ETEC)腹泻是一种高度地方性腹泻 埃及儿童，估计累计发病率为2.4 有症状的ETEC发作从出生到36个月，并且平衡 毒素表型的分布。这些功能使其合乎逻辑 建立一个用于评估ETEC流行病学和ETEC的现场站点 埃及的疫苗。最近，我们开始了一个合作项目，以 在Abees(亚历山大附近)开发一个用于儿科研究的网站 拉肚子。该项目将遵循以下儿科队列 目的：1)确定ETEC腹泻的年龄别发病率 从出生到35月龄，受毒素和定居因子(CFA)表型的影响； 2)确定腹泻症状归因于粪便的强度 ETEC的分离；3)评价两者之间的保护关系 ETEC毒素和CFAs血清免疫球蛋白抗体滴度与发病风险的关系 ETEC引起的腹泻表现出这些毒力因子。努力做到这一点 该项目于1993年6月开始；到目前为止，工作的重点是礼宾 设计、数据表格开发、数据计算机系统开发 录入和管理，以及编制程序手册。它是 预计队列研究将在进行预测试验后开始 1993年11月。

Enterotoxigenic Escherichia coli (ETEC) diarrhea is hyperendemic among young Egyptian children, with an estimated cumulative incidence of 2.4 symptomatic ETEC episodes from birth to 36 months, and a balanced distribution of toxin phenotypes. These features make it logical to develop a field site for the evaluation of ETEC epidemiology and ETEC vaccines in Egypt. Recently, we have begun a collaborative project to develop a site in Abees (near Alexandria) for the study of pediatric diarrhea. This project will follow a pediatric cohort with the following aims: 1) to determine the age-specific incidence rate of ETEC diarrhea from birth to 35 months, by toxin and colonization factor (CFA) phenotype; 2) to ascertain the strength of attribution of diarrheal symptoms to fecal isolation of ETEC; 3) to evaluate the protective relationship between titers of serum IgG antibodies to ETEC toxins and CFAs and the risk of diarrhea due to ETEC manifesting these virulence factors. Work on this project began in June, 1993; the work thus far has focused on protocol design, data form development, development of computer systems for data entry and management, and preparation of manuals of procedures. It is anticipated that the cohort study will, after conduct of a pretest, begin in November, 1993.