FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

该项目需要继续分析来自一个大型的数据库的数据， B亚单位灭活的全细胞（BS-1）的大规模安慰剂对照田间试验 WC）和灭活的全细胞（WC）口服霍乱疫苗， 1985年至1990年在Matlab领域进行了研究， 孟加拉国国际腹泻病研究中心。 的 试验入组病例89，000名研究对象。 对前三个的分析 几年的随访显示，每种疫苗都赋予CA。50%保护 预防在前往医院求诊的病人中发现的霍乱病例 设施 目前正在开展更多工作，以确定是否存在 幽门螺杆菌感染，一种已知的持续性 在孟加拉国，低氯血症是霍乱的一个危险因素。 本研究 正在评估H.霍乱个案中的幽门螺杆菌感染 和社区控制在现场试验期间组装。

This project entails continuing analyses of data derived from a large- scale, placebo-controlled field trial of B subunit-killed whole cell (BS- WC) and killed whole cell-only (WC) oral vaccines against cholera, conducted between 1985-90 in the Matlab field studies area of the International Center for Diarrheal Disease Research, Bangladesh. The trial enrolled ca. 89,000 subjects for study. Analyses of the first three years of follow-up revealed that each vaccine conferred ca. 50% protection against cholera episodes detected among patients seeking care at medical facilities. Additional work is ongoing to determine whether antecedent infection by Helicobacter pylori, a known cause of persistent hypochlorhydria, is a risk factor for cholera in Bangladesh. This study is evaluating serological evidence of H. pylori infection in cholera cases and community controls assembled during the field trial.