COMPREHENSIVE SICKLE CELL CENTER

哥伦比亚大学综合镰刀细胞中心包括 内科和外科医学院的科学资源和 其3家主要医院的临床资源：长老会医院、圣彼得堡医院。 卢克医院/罗斯福和哈莱姆医院。 该中心将继续提供优质的临床护理、筛查、 对儿童社区进行遗传咨询、产前诊断和教育 曼哈顿的上半部分，那里是病人最集中的地方 患有镰状细胞病(SCD)的人和他们的家人生活在一起。 该中心将包括8个研究单位、3个临床单位(每个单位一个 医院)和2个核心单位。研究单位将独家 致力于研究；临床单位还将提供临床 护理、筛查和教育。 研究的领域如下： 转移β-珠蛋白基因， 转HgbS基因小鼠的制备与研究 汞原子分子的相互作用和聚集， SCD中的红系前体， SCD的微血管功能， SCD的脑血管循环， SCD的神经参与， 骨髓移植在SCD中的应用 两个核心单位还将提供分子生物学分析，产前 诊断、血液学检测、数据管理、统计和 行政管理。 该中心的目标是促进改善以下领域的知识 镰状细胞疾病，并提供一个环境，在那里 各种研究项目产生的场可能会带来 立即送到病人手中。

The Comprehensive Sickle Cell Center of Columbia University includes the scientific resources of the College of Physicians and Surgeons and the clinical resources of its 3 main hospitals: Presbyterian, St. Luke's/Roosevelt and Harlem Hospital. The Center will continue to provide excellent clinical care, screening, genetic counseling, prenatal diagnosis and education to the community of the upper part of Manhattan, where the largest concentration of patients with sickle cell diseases (SCD) and their families live. The Center will include 8 research units, 3 clinical units (one at each hospital) and 2 core units. The research units will be exclusively dedicated to research; the clinical units will also provide clinical care, screening and education. The areas of research will be the following: Transfer of the beta-globin gene, Production and study of transgenic mice containing HgbS, Interactions and aggregation of HgbS molecules, Erythropoietic precursors in SCD, Microvascular function in SCD, Cerebro-vascular circulation in SCD, Neurological involvement in SCD, Bone marrow transplantation in SCD. Two core units will also provide molecular biology analysis, prenatal diagnosis, hematological testing, data management, statistics and administration. The goal of the Center is to foster improved knowledge in the area of sickle cell diseases and to provide an environment where the advances in the field generated by the various research projects may be brought immediately to the patients.