APPLICATION OF FLOW CYTOMETRY TO CELL BIOLOGY

实验免疫学分院流式细胞仪实验室 支持55名以上研究人员的多个研究项目。 这些研究包括定量的单细胞分析 与新鲜从不同来源制备的细胞相关的参数 物种/组织，以及体外培养细胞的光谱。基本信息 向欧洲投资银行的成员以及其他成员提供研究支持 DCBDC内部的调查人员。目前支持的项目包括，但 不限于以下研究领域：a)体内和体外研究 通过T细胞表面分子分析细胞内信号，b) 遗传免疫和诱导免疫动物的细胞缺陷分析 功能障碍；c)移植物抗宿主病发病机制研究； D)细胞黏附的坐标细胞表面表达的分析 分子；e)T细胞个体发育和分化的研究；f) T细胞库生成机制的研究；g)分析 移植抗原的表达；h)机制的研究 参与抗原呈递过程；以及i)分析 骨髓移植排斥与接受的机制。

The Experimental Immunology Branch flow cytometry laboratory currently supports multiple research projects for more than 55 investigators. These investigations involve quantitative single cell analysis of parameters associated with cells freshly prepared from different species/tissues, as well as a spectrum of in vitro cultured cells. Basic research support is provided to members of the EIB as well as to other investigators within DCBDC. Currently supported projects include, but are not limited to, the following areas of study: a) in vivo and in vitro analyses of intra-cellular signalling via T cell surface molecules, b) analyses of cellular defects in animals with genetic or induced immune dysfunction; c) studies of the pathogenesis of graft-versus-host disease; d) analyses of the coordinate cell surface expression of cell adhesion molecules; e) investigations of T cell ontogeny and differentiation; f) studies of mechanisms of T cell repertoire generation; g) analyses of expression of transplantation antigens; h) investigations of mechanisms involved in antigen presentation processes; and i) analyses of the mechanisms involved in marrow graft rejection versus acceptance.