EXPRESSION OF IL-4 RECEPTORS ON HUMAN TUMORS

本研究旨在探讨IL-4 R在胃癌细胞中的表达以及IL-4在胃癌细胞中的作用。 IL-4对人实体肿瘤的作用 我们已经观察到， 不同组织学也表达IL-4 R。 人乳腺癌，卵巢 癌、黑色素瘤和肾肿瘤系，以及新鲜肿瘤 从NCI获得，表达高亲和力IL-4 R。 特点 这些受体似乎是类似的报告造血 细胞如T细胞、B细胞、肥大细胞和巨噬细胞。 人类肿瘤 也表达单一种类的IL-4 R mRNA。 我们目前正在 探讨IL-4对肿瘤细胞的作用。 我们的初步数据 表明IL-4对某些IL-4 R阳性细胞具有直接生长抑制作用 MTT法检测肿瘤细胞的增殖。 此外，IL-4似乎 上调某些肿瘤细胞上的HLA-DR抗原。 实验正在进行中 其将检测IL-4 R对肿瘤细胞的调节。 这个项目 目前处于活跃状态。

In this project, we are studying the expression of IL-4R and the role of IL-4 on solid human tumors. We have observed that human tumors of different histology also express IL-4R. Human breast carcinoma, ovarian carcinoma, melanoma and renal tumor lines, as well as fresh tumors obtained from the NCI, express high affinity IL-4R. The characteristics of these receptors appear to be similar to that reported on hematopoetic cells such as T cells, B cells, mast cells and macrophages. Human tumors also express a single species of IL-4R mRNA. We are currently investigating the function of IL-4 on tumor cells. Our preliminary data indicate that IL-4 is directly growth inhibitory to some IL-4R positive tumor lines as tested by MTT assay. Furthermore, IL-4 appear to upregulate HLA-DR antigen on some tumor cells. Experiments are underway which will examine the regulation of IL-4R on tumor cells. This project is currently active.