PLATELET ANTIGENS AND PLATELET ACTIVATION

我们已经开发了几种方法来研究体外和 试管内。这些研究是由于发展和 从人血中分离血小板的技术实现 诱导血小板活化或分泌。我们已经开发出九(9)个 仅与激活的血小板发生反应的单抗。我们的 结果表明，在某些形式的von Willebrand病中，血小板 激活存在，并导致血小板减少。在患有 动脉硬化性心脏病运动后血小板活化 减少了。这表明，某些程度的血小板活化发生在 这些患者在剧烈运动后。在志愿者接待中 内毒素自发激活或增强激动剂诱导的血小板活化 未观察到血小板活化。

We have developed several methods to study platelet activation ex-vivo and in-vitro. These studies were made possible by the development and implementation of techniques to isolate platelets from human blood without inducing platelet activation or secretion. We have developed nine (9) monoclonal antibodies which react only with activated platelets. Our results have shown that in some forms of von Willebrand's disease platelet activation is present and causes thrombocytopenia. In patients with arteriosclerotic heart disease after exercise platelet activation is decreased. This suggests that some degree of platelet activation occurs in these patients following strenuous exercise. In volunteers receiving endotoxin spontaneous platelet activation or enhanced agonist-induced platelet activation is not observed.