SURFACTANT METABOLISM IN AIDS PATIENTS WITH PNEUMOCYSTIS CARINII PNEUMONIA

慢性阻塞性肺疾病患者低氧血症及气体交换减少的机制 已治疗和未治疗的肺孢子虫肺炎并不干净。Dr。 霍夫曼开发了一种测量表面活性物质的微型技术。 支气管肺泡灌洗液中的脂类。到目前为止，已经有21个样品 学习。有证据表明，表面活性物质的脂质分解增加了 溶血磷脂酰胆碱。也有证据表明， 这些患者灌洗液中磷脂酶A2的活性。这个 这些研究的重要性在于，这些观察可能允许 在这一患者群体中开发新的或不同的治疗方法。一个 手稿正在准备中。

The mechanisms of hypoxemia and of declining gas exchange in patients with treated and untreated pneumonia due to pneumocystis is not clean. Dr. Hoffman has developed a microtechnique for the measurement of surfactant lipids from Bronchoalveolar Lavage Fluid. To date, 21 samples have been studied. There is evidence of surfactant lipid breakdown with an increase in lysophosphatidyl choline. There is also evidence of increased Phospholipase A2 activity in the lavage Fluid of these patients. The importance of these studies is that these observations may allow for the development of new or different therapies in this patient population. A manuscript is in preparation.