CLINICAL STUDIES ON INTRAOPERATIVE RADIATION THERAPY

国家癌症放射肿瘤学分会和外科分会 研究所已经参与了前瞻性随机研究 评价术中放射治疗的潜在作用 几个病变部位，包括可切除和不能切除的癌 胰腺癌、可切除的胃癌和腹膜后癌 肉瘤。已有100名患者接受了实验性的 术中放射治疗，随机接受或不接受 术中接受大剂量单次放射治疗 电子。确实没有任何迹象表明存活率有所提高，或者 在无病生存方面。有一些建议可以改善…… 腹膜后自身的局部控制；然而，这被 有很高的腹膜腔种植倾向， 腹膜癌或肉瘤病，从而中和 术中放射治疗的潜在益处。胰腺的临床试验 癌症和腹膜后肉瘤已经关闭。胃病 研究仍在进行中，以获得患者的收益。

The Radiation Oncology Branch and Surgery Branches of the National Cancer Institute have been involved in prospectively randomized studies evaluating the potential role of intraoperative radiation therapy in several disease sites, including resectable and unresectable carcinomas of the pancreas, resectable carcinomas of the stomach and retroperitoneal sarcomas. One hundred patients have been treated with experimental intraoperative radiation therapy, and randomized to either receive or not receive radiation therapy intraoperatively with large single doses of electrons. There is really no suggestion of improvement in survival, or in disease-free survival. There is some suggestion of an improvement of local control in the retroperitoneum itself; however, this is off-set by a high predilection for seeding of the abdominal cavity, either peritoneal carcinomatosis or sarcomatosis, thus neutralizing the potential benefit of intraoperative radiation. The trials on pancreatic carcinoma and retroperitoneal sarcomas have been closed. The gastric study is still open for patient accrual.