PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSE IN HAIR

在人类头发样本中检测到药物残留的方法有多种 分析技术。这些报道引起了人们的极大兴趣 使用头发作为药物使用的历史记录。研究是设计的 确定人体内滥用药物的存在和时程 头发。 有化学物质滥用史的健康男性志愿者会 参与研究。将获得知情同意，所有 程序将由医院机构审查委员会批准。 受试者将居住在ARC的临床病房。头部和面部 头发样本将在服用之前和之后进行采集 滥用药物。还将采集血液、唾液和尿液样本。 对药物的组织和生物体液的分析将由 放射免疫分析和气相色谱/质谱仪。 这些研究将为测定水杨酸的含量提供科学依据。 头发作为药物滥用的“历史记录”的有用性。

Drug residues have been detected in human hair specimens by a variety of analytical techniques. These reports have generated substantial interest in using hair as a historical record of drug usage. Studies are designed to determine the presence and time course of drugs of abuse in human hair. Healthy male volunteers with a history of chemical substance abuse will participate in the study. Informed consent will be obtained and all procedures will be approved by the hospital Institutional Review Board. Subjects will reside on the clinical ward of the ARC. Head and facial hair specimens will be obtained prior to and after administration of drugs of abuse. Blood, saliva and urine specimens also will be obtained. Analyses of tissue and biofluids for drug will be performed by radioimmunoassay and gas chromatography/mass spectrometry. The studies will provide the scientific basis for determination of the usefulness of hair as a "historical record" for substance abuse.