MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
批准号:
3839168
负责人:
J O CISAR
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Actinomyces bacterial antigens bacterial polysaccharides bacterial proteins dental caries dental plaque ecology gene expression genetic strain gram negative bacteria hydroxyapatites lectin microorganism interaction molecular pathology oral bacteria receptor binding receptor expression saliva surface antigens
中文摘要
71株绿色链球菌,归类为
血链球菌、戈登链球菌、口腔链球菌、米氏链球菌或绞股链球菌,
通过修订的分类方案,对它们进行了表征和比较
与粘附性相关的特定属性。显著差异是
在物种之间记录的。血链球菌、戈登链球菌和口腔链球菌
共同表达的神经氨酸酶敏感血凝活性
而酸性富含脯氨酸蛋白的乳胶珠的聚集
主要以后两个种的菌株为标志。更多菌株
血链球菌、戈登链球菌和口腔链球菌明确地附着于
唾液包被的羟基磷灰石比米蒂斯链霉菌和链球菌属的菌株更好。
心绞痛。注意到与放线菌形成的乳糖抗性共聚体。
最常见的是戈登氏链球菌和绞股沟链球菌,没有涉及的物种
在牙齿的原始定植过程中。相比之下,乳糖敏感
所有菌株均能与放线菌形成共聚体。
口腔感染较少,与其他链球菌属的感染较少。许多
其中链球菌也参与了对GalNAc敏感
与某些血链球菌和戈登氏链球菌的凝聚。
含有Gal和GalNAc敏感凝集素的放线菌和含有Gal和GalNAc敏感凝集素的链球菌
GalNAc敏感凝集素都与口腔沙门氏菌34共同聚集,但这些
细菌没有与菌株34的自发突变株共同聚集
缺乏先前显示含有的细胞壁多糖
GalNAcbeta13Ga1α受体区域。已知拥有的其他菌株
含有该二糖的细胞壁多糖也共同聚集
链球菌表达GalNAc敏感凝集素。不像
放线菌凝集素,链球菌凝集素未能识别
其他链球菌多糖受体中的Galbeta13GalNAcalpha。
某些粘附性与不同分类的关联
绿色链球菌群及其特异性的定义
其中一些相互作用为进一步的生态
这些口腔细菌的特征。
英文摘要
Seventy-one strains of viridans streptococci, classified as
Streptococcus sanguis, S. gordonii, S. oralis, S. mitis or S. anginosus,
by a revised taxonomic scheme, were characterized and compared by their
specific adherence related properties. Significant differences were
noted between species. Strains of S. sanguis, S. gordonii and S. oralis
commonly expressed neuraminidase sensitive hemagglutinating activities
while aggregation of acidic proline rich protein coated latex beads was
noted primarily with strains of the latter two species. More strains of
S. sanguis, S. gordonii and S. oralis were specifically adherent to
saliva-coated hydroxyapatite than were strains of S. mitis and S.
anginosus. Lactose resistant coaggregations with actinomyces were noted
most frequently with S. gordonii and S. anginosus, species not involved
in the primary colonization of teeth. In contrast, lactose sensitive
coaggregations with actinomyces were observed with all strains of S.
oralis and less frequently with the other streptococcal species. Many
of these streptococci also participated in GalNAc sensitive
coaagregations with certain S. sanguis and S. gordonii strains.
Actinomyces with Gal and GalNAc sensitive lectins and streptococci with
GalNAc sensitive lectins both coaggregated with S. oralis 34 but these
bacteria did not coaggregate with a spontaneous mutant of strain 34 that
lacked a cell wall polysaccharide previously shown to contain
GalNAcbeta13Ga1alpha receptor regions. Other strains known to possess
cell wall polysaccharides containing this disaccharide also coaggregated
with streptococci expressing GalNAc sensitive lectins. Unlike
actinomyces lectins, the streptococcal lectins failed to recognize
Galbeta13GalNAcalpha in polysaccharide receptors of other streptococci.
The association of certain adherence properties with different taxonomic
groups of viridans streptococci and definition of the specificities of
some of these interactions provide a basis for further ecological
characterization of these oral bacteria.
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MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3939937
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3917099
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
MOLECULAR BIOLOGY OF STREPTOCOCCAL RECEPTOR POLYSACCHARIDES
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批准号:2456751
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3963708
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:4692619
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资助金额:$0.0万
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3875195
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资助金额:$0.0万
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3854182
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资助金额:$0.0万
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3753492
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:3775623
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
MICROBIAL ANTIGENS ASSOCIATED WITH SPECIFIC ADHERENCE
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批准号:5201760
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J O CISAR
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依托单位:
海外基金