MOUSE MUTANT GENE RESOURCE

这个项目的具体目标是：1.采购潜在的新产品 有价值的小鼠神经学、免疫学和内分泌突变体 在杰克逊的繁殖群体中自发发生的 实验室；2.尊重对新突变的基因特征 对遗传方式、等位基因和连锁关系的影响； 描述新的突变体在生育力方面的表型， 寿命、生长、活力和行为；4.为了研究解剖学， 所选新突变体的组织病理学和生理异常； 5.选育适合维护和研究新品种的菌株 已建立的小鼠突变以保持突变和正常等位基因 在统一的遗传背景上进行分离；6.保存已建立的 作为冷冻胚胎的突变体，以确保其继续可用； 向科学界提供突变和携带突变基因的小鼠。

The specific aims of this project are: 1. To procure new potentially valuable neurological, immunological and endocrinological mutants of mice that occur spontaneously in the breeding colonies of the Jackson Laboratory; 2. To characterize the new mutations genetically with respect to mode of inheritance, allelism, and linkage relationship; 3. To characterize the new mutants phenotypically with respect to fertility, longevity, growth, viability, and behavior; 4. To study the anatomical, histopathological, and physiological abnormalities of selected new mutants; 5. To develop suitable strains for maintaining and studying new and established mouse mutations so as to keep the mutant and normal allele segregating on a uniform genetic background; 6. To preserve established mutants as frozen embryos to assure their continued availability; 7. To make mutants and mutant-bearing mice available to the scientific community.