DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA

药物滥用后人类受试者唾液中药物的存在 管理进行了研究，以确定药物测试的可行性 唾液。 有化学物质滥用史的健康男性受试者 自愿参加研究 获得了知情同意书，所有 该程序由医院机构审查委员会批准。 在服用可卡因、大麻或鸦片制剂后，唾液和 定期采集血样。 行为和生理 在收集生物流体的同时进行测量。 样品 采用放射免疫分析和气相色谱/质谱联用技术进行分析。 发现血液水平与唾液水平显著相关 可卡因和鸦片 对大麻的调查仍在继续。 这些研究为开发新的 药物滥用的非侵入性检测

The presence of drugs of abuse in saliva of human subjects after drug administration was studied to determine the feasibility of drug testing with saliva. Healthy male subjects with a history of chemical substance abuse volunteered for the studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiate, saliva and blood samples were collected periodically. Behavioral and physiological measures were made concurrently with collection of biofluids. Samples were analyzed by RIA and gas chromatography/mass spectrometry. Significant correlations of blood levels with saliva levels were found for cocaine and opiates. Investigations are continuing on marijuana. These studies provide the scientific basis for development of new non-invasive tests for drug abuse.