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MOLECULAR FORCES IN CELLUALR ORGANIZATION AND FUNCTION

MOLECULAR FORCES IN CELLUALR ORGANIZATION AND FUNCTION
细胞组织和功能中的分子力
批准号：
3853607
负责人：
V A PARSEGIAN
金额：
$0.0万
依托单位：
CENTER FOR INFORMATION TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3853607
关键词：
cell biology cell membrane cell osmotic pressure macromolecule

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中文摘要
翻译
我们工作的主题一直是衡量、识别和制定 对大分子的组织和结构至关重要的力 膜。 具体地说，使用渗透应激技术，我们测量了力与 有序排列的膜之间或大分子之间的距离。我们 已经发现以前和现在普遍存在的部队性质 假设是为了解释分子组织和亚细胞组装 是不准确的。不过，令人高兴的是，相当广泛的 我们正在获取的信息使我们打开了新的思考方式 关于细胞功能的分子基础。
英文摘要
The theme of our work has been to measure, to identify, and to formulate the forces that are important to the organization of macromolecules and membranes. Specifically, using the osmotic stress technique we have measured force vs. distance between membranes or between macromolecules in ordered arrays. We have found that the nature of the forces previously and still commonly assumed in order to explain molecular organization and subcellular assembly are not accurate. Happily, though, the fairly extensive catalog of information that we are acquiring is allowing us to open new ways to think about the molecular basis of cellular function.
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DIRECT MEASUREMENT OF FORCES BETWEEN MEMBRANES OR MACROMOLECULES
PHYSICS OF IONIC CHANNELS AND OTHER PROTEINS WITH AQUEOUS CAVITIES
DIRECT MEASUREMENT OF FORCES BETWEEN MEMBRANES OF MACROMOLECULES
DIRECT MEASUREMENT OF FORCES BETWEEN MEMBRANES OR MACROMOLECULES
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