NATURAL HISTORY AND TREATMENT OF CHRONIC NON-A, NON-B HEPATITIS

有充分证据的慢性非甲非乙型肝炎患者正在接受 评估以确定这种常见形式的长期自然历史 慢性肝病。有一组这样的患者可以进行评估 实验性疗法。先前的研究表明，α干扰素 治疗对大约50%的患者有短期的益处。 在治疗过程中，有益的反应持续在 停用干扰素后约20%。利巴韦林的初步研究 对14例慢性丙型肝炎患者进行了治疗。 所有患者的转氨酶在治疗过程中都有所下降，并成为 正常5例(36%)。血清丙型肝炎病毒核糖核酸水平也显著下降。 在治疗期间。

Patients with well-documented chronic non-A, non-B hepatitis are being evaluated to determine the long-term natural history of this common form of chronic liver disease. A cohort of such patients are available to evaluate experimental therapies. Previous studies have shown that alpha interferon therapy has a short-term beneficial effect in approximately 50% of patients during treatment and that the beneficial response is sustained in approximately 20% after stopping interferon. A pilot study of ribavirin therapy has been conducted in 14 patients with chronic hepatitis C. Serum aminotransferases decreased during therapy in all patients and became normal in 5 (36%). Serum levels of HCV RNA also decreased significantly during therapy.