PENTOSAN POLYSULFATE AS PROPHYLAXIS FOR MIGRAINE

聚硫酸戊聚糖(PPS)是一种半合成聚阴离子，一直处于 在这里进行了多年的调查，作为预防治疗 偏头痛和丛集性头痛。这些先导研究都是单盲的。 结果已经足够令人鼓舞，足以证明双盲是合理的。 确认或反驳临床数据的方案。 反应的主要预测因素是循环中的嗜碱性粒细胞计数较低。 一项协议已获批准，该协议涉及筛查 偏头痛患者，选择嗜碱性粒细胞计数较低的患者并将其随机化 进入一项双盲安慰剂对照研究。

Pentosan polysulfate (PPS), a semi-synthetic polyanion, has been under investigation here for a number of years as a prophylactic treatment for migraine and cluster headache. These pilot studies were all single blind. Results have been sufficiently encouraging to justify a double blind protocol to confirm or refute the clinical data. The main predictor of response has been a low circulating basophil count. A protocol has been approved which involves screening a population of migraineurs, selecting those with low basophil counts and randomizing them into a double blind placebo controlled study.