MOLECULAR RESOURCES FACILITY ENHANCEMENT

该提案要求为购置文书提供资金， 扩大分子资源的核心因素在大学 罗切斯特。 具体而言，梯度HPLC系统、寡核苷酸 合成器和制备超浓缩物需要提高 我们目前高度使用的蛋白质纯化和核酸核心 laboratories. 此请求得到以下主要用户组的支持： 31名研究人员和新的教师组成了一个 二级用户组。 适当的机构支助已 承诺提供技术援助，建设新的核心实验室 设施，并购买所需的配套设备。 该设施 位于医疗中心的中心位置，教职员工很容易到达 所有医学院部门的人员，也被用来 作为本系研究人员的核心设施。生物学。 的 分子资源核心是由训练有素的技术人员组成， 每个组成部分都在一名教师的指导下， 该地区 由亚伯拉罕博士领导的设施咨询委员会，以及 由Barbara Iglewski博士（微生物学主席），Martin博士 Gorovsky（生物学主席）和Fred谢尔曼博士（ 生物化学），监测设施的使用和运作。 的 分子资源核心已经发挥了其预期的功能， 医学中心和大学研究人员的活跃中心 到目前为止，它已经令人钦佩地履行了预期的职能。

This proposal requests funds for the acquisition of instruments to augment the MOLECULAR RESOURCES CORE FACILITY at the University of Rochester. Specifically, gradient HPLC systems, oligonucleotide synthesizers, and preparative ultracentrifuges are required to enhance our present and highly used protein purification and nucleic acid core laboratories. This request is supported by a primary user group of THIRTY-ONE investigators and additionally new faculty who comprise a secondary user group. Appropriate institutional support has been committed for technical assistance, construction of new core laboratory facilities, and purchase of required supporting equipment. The facility is centrally located in the medical center and easily accessed by faculty and personnel in all of the Medical School departments, and is also used as the core facility for researchers in the dept. of Biology. The MOLECULAR RESOURCES CORE i.s staffed by trained technical personnel, and each component is under the guidance of a faculty member who is an expert in the area. A facility advisory committee headed by Dr. Abraham, and comprised of Dr. Barbara Iglewski (chair of Microbiology), Dr. Martin Gorovsky (chair of Biology) and Dr. Fred Sherman (chair of Biochemistry), monitors the use and functioning of the facility. The Molecular Resources Core has served its intended function of forming an active center for researchers in the medical center and University departments and has thus far admirably fulfilled its intended function.