DEFINING NONCLASSICAL ANGIOTENSIN SIGNALLING AND CARDIOVASCULAR FUNCTION

血管紧张素II是一种荷尔蒙，众所周知，它会导致高血压和心血管疾病。这项提议将使用我们合成的高度新颖的化合物，这些化合物首次选择性地针对非经典的血管紧张素相关结合部位，即所谓的非AT1受体，这些受体被认为可以抵消血管紧张素II的有害影响，血管紧张素II通常会导致心脏纤维化或结疤，损害健康的肌肉。

Angiotensin II is a hormone which is well known to contribute to high blood pressure and cardiovascular disease. This proposal will use highly novel compounds that we have synthesised that, for the first time, selectively target nonclassical angiotensin-related binding sites, so called NON-AT1 receptors, which are thought to counteract the deleterious effects of angiotensin II that normally causes fibrosis or scarring of the heart which damages healthy muscle.