MHC CLASS II ANTIGENS IN THE PATHOGENESIS OF INFLAMMATORY DISEASES

MHC II类抗原，人类中的HLADR和小鼠中的1a，是 主要致病基因编码的膜结合糖蛋白 组织相容性复合体。这些抗原的表达具有重要的意义。 免疫的启动和持续的功能重要性 回应。在许多免疫病理条件下，人类白细胞抗原-DR 抗原阴性细胞被刺激表达II类抗原。在……里面 在这些病例中，已经推测第二类病毒在免疫学上起作用。 抗原表达。 我们发现细胞因子激活的RPE细胞表达MHC-II类抗原。 这些la阳性细胞既能处理视网膜抗原，又能提呈它们。 到特别敏感的T辅助淋巴细胞术。这些研究表明 细胞因子激活的RPE细胞可能是眼球的基本成分 豁免权。 局部自身免疫中MHC-II类抗原表达的研究 疾病提供的证据表明，这些抗原的激活可能 在这些疾病的免疫发病机制中起着重要作用。

MHC class II antigens, HLA-DR in the human and la in the mouse, are membrane-bound glycoproteins encoded by genes of the major histocompatibility complex. Expression of these antigens is of great functional importance for the initiation and perpetuation of immune responses. In a number of immunopathologic conditions, HLA-DR antigen-negative cells are stimulated to express class II antigens. In these cases, an immunologic role has been postulated for the class II antigen expression. We showed that cytokine-activated RPE cells express MHC class II antigens. These la-positive cells can both process retinal antigens and present them to specifically sensitive T-helper lymphoctyes. These studies indicated that cytokine activated RPE cells may be a basic component of ocular immunity. These studies on MHC class II antigen expression in localized autoimmune diseases provide evidence that the activation of these antigens may contribute to the immunopathogenesis of these diseases.