EFFECT OF ANTIDEPRESSANT DRUG ON SENSITIVITY OF THE CIRCADIAN PACEMAKER TO LIGHT

本项目研究抗抑郁药物对光的影响 生物钟的敏感性。生物钟有助于调节 人类行为的日常模式暴露在光线下会重置 生物钟和由生物钟控制的行为模式。的药物 改变时钟对光的响应性， 环境与内生性之间的关系 生理过程。 在许多哺乳动物中，生物钟由两个振荡器组成， 控制早晚活动。这些振荡器表现出不同的 它们对光的反应。例如，晨光前进 昼夜节律起搏器的时间通过相移早晨 振荡器夜晚的光线延迟了昼夜节律起搏器的时间， 使晚间振荡器移相。我们的数据表明， 抗抑郁药氯吉林的治疗 对早晨和傍晚的光线敏感。 这种灵敏度的变化有助于建立新的稳定的 昼夜节律起搏器和环境之间的相位关系。 然而，由于它们对光的敏感性不同， 光脉冲可以驱动昼夜节律系统的内源性成分进入 相对于体温节律的不稳定相位关系。 这些作用可能与其抗抑郁机制有关。 药物，或紊乱的睡眠-觉醒周期，有时观察到， 人类

This project investigates the effect of antidepressant drugs on the light sensitivity of the circadian clock. The circadian clock helps to regulate the daily pattern of human behavior. Exposure to light resets the timing of the clock and the pattern of behaviors controlled by the clock. Drugs that alter the responsiveness of the clock to light reset the temporal relationship that exists between the environment and endogenous physiological processes. In many mammals, the circadian clock consists of two oscillators that control morning and evening activity. These oscillators exhibit different properties in their response to light. For example, morning light advances the timing of the circadian pacemaker by phase-shifting the morning oscillator. Evening light delays the timing of the circadian pacemaker by phase-shifting the evening oscillator. Our data suggests that chronic treatment with the antidepressant drug clorgyline differentially affects light sensitivity to morning and evening light. This change in sensitivity contributes to the establishment of new stable phase relationships between the circadian pacemaker and the environment. However, due to their different sensitivities to light, high intensity light pulses may drive endogenous components of the circadian system into unstable phase relationships with respect to the body temperature rhythm. These effects may be related to the antidepressant mechanisms of these drugs, or to the disorganized sleep-wake cycle sometimes observed in humans.