BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA

我们的计划在这个修订后的申请神经科学中心， 精神分裂症（CNS）代表了协作的自然产物， 存在于基础和临床的大型社区内的相互作用 神经科学家在校园 考虑到精神分裂症患者的异质性 综合征和缺乏共识，关于其发病机制，我们 我认为，多样化和多学科的方法是最重要的， 适当的概念观点，将神经科学和 精神分裂症 因此，基础和临床的科学领域 本申请中提出的调查故意包括广泛的 动物脑功能研究的主题和方法 和人类实验对象。 该中心将由临床核心组成;以及 四大研究项目。 临床中心将承担 招募、临床评估、管理、维护和随访 当前和未来研究所需的临床和正常受试者， 包括那些与种子资金计划有关的人。 这一工作将 此外，进行神经心理学，自身免疫，睡眠，认知， 治疗调查。 提出的四项重点研究计划 包括网络中改变的神经生理学研究 大鼠海马神经元的特性， 猴子的前额皮质， 多巴胺能神经元和多巴胺释放的神经化学研究 大鼠前脑和临床在体NMR评估的结构和 精神分裂症患者大脑的代谢变化。正如所 预计，某些共同的主题贯穿四个方案。 为 例如，额叶皮质功能障碍在脑卒中病因学中的作用， 精神分裂症在程序2、3和4中被假定， 典型和非典型精神抑制剂的作用与所有四个相关 程序. 我们投资这个项目的最大希望和理由 是参与科学和相互教育活动 基础神经科学家和临床研究者之间的联系， 一个这样的中心，以及这种生产力的出现， 新的假设和模式的合作互动， 这些共同关心的问题，以及未来的发展， 一代又一代的调查人员将接受充分的意志训练， 有能力在基础和临床之间建立成功的联系 神经科学相关的主要精神障碍。

Our plans in this revised application for the Center for Neuroscience in Schizophrenia (CNS) represent a natural outgrowth of the collaborative interactions that exist within the large community of basic and clinical neuroscientists on campus. Given the heterogeneity of the schizophrenic syndrome and the lack of consensus regarding its pathogenesis, we believe that a diverse and multidisciplinary approach is the most appropriate conceptual perspective for relating neuroscience and schizophrenia. Consequently, the scientific areas of basic and clinical investigations proposed in this application deliberately include a wide range of topics and approaches to the study of brain function in animal and human subjects. The Center will consist of the Clinical Core; and four major research programs. The Clinical Core will undertake the recruitment, clinical assessment, management, maintenance, and follow-up of clinical and normal subjects required for current and future studies, including those associated with the Seed Money Program. It will, in addition, conduct neuropsychological, autoimmune, sleep, cognitive, and treatment investigations. The four key research programs proposed encompass neurophysiological studies of the alterations in the network properties of hippocampal neurons in rats, neuronanatomical studies of the prefrontal cortex in monkeys , neurophysiological studies of dopaminergic neurons and neurochemical studies of dopamine release in rat forebrain and clinical in vivo NMR assessment of structural and metabolic changes in the brains of schizophrenic patients. As might be expected, certain common themes run through the four programs. For example, a role for frontal cortical dysfunctions in the etiology of schizophrenia is presumed in Programs 2, 3, and 4 and the biological actions of typical and atypical neuroleptics are relevant to all four programs. Our greatest hope and reason for investment in this venture is in the participatory scientific and mutual educational activities between basic neuroscientists and clinical investigators that we see in a Center of this kind, and the emergence from such productive collaborative interactions of new hypotheses and modes for approaching these issues of joint concern, as well as the development of the next generations of investigators who will be sufficiently will trained and equipped to develop successful links between basic and clinical neuroscience relevant to major mental disorders.