Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer
Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer
批准号:
nhmrc : 1084772
负责人:
Prof Stuart Pitson
金额:
$40.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
鞘氨醇激酶是一种蛋白质,当失调时参与癌症的发展和进展。我们最近在这一领域取得了重大突破,发现了一种天然存在的鞘氨醇激酶变体,这种变体不断被激活,并具有增强的诱发癌症的能力。在这项研究中,我们将研究和靶向这种形式的鞘氨醇激酶作为一种潜在的治疗干预癌症。
英文摘要
Sphingosine kinase is a protein that when dysregulated is involved in cancer development and progression. We have recently made a substantial breakthrough in this area by identifing a naturally occuring variant of sphingosine kinase that is constantly activated and has an enhanced ability to induce cancer. In this study we will examine and target this form of sphingosine kinase as a potential therapeutic intervention in cancer.
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会议论文
Targeting sphingolipid metabolism in disease
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批准号:nhmrc : GNT1156693
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项目类别:Research Fellowships
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资助金额:$64.92万
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财政年份:2019
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase as a target for anti-cancer therapy
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批准号:nhmrc : GNT1042589
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项目类别:Research Fellowships
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资助金额:$59.08万
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财政年份:2013
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase as a target for anti-cancer therapy
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批准号:nhmrc : 1042589
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项目类别:Research Fellowships
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资助金额:$50.1万
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财政年份:2013
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负责人:Prof Stuart Pitson
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依托单位:
Targetting the CIB1-sphingosine kinase interaction in oncogenesis
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批准号:nhmrc : 1004695
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项目类别:Project Grants
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资助金额:$53.68万
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财政年份:2011
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负责人:Prof Stuart Pitson
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依托单位:
Role of sphingosine kinase 1 in PP2A-associated tumorigenesis
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批准号:nhmrc : 626937
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项目类别:NHMRC Project Grants
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资助金额:$34.87万
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财政年份:2010
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负责人:Prof Stuart Pitson
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依托单位:
Mechanisms of regulation and biological roles of sphingosine kinase 2
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批准号:nhmrc : 626936
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项目类别:NHMRC Project Grants
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资助金额:$34.54万
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财政年份:2010
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负责人:Prof Stuart Pitson
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依托单位:
The role of SKAM and sphingosine kinase in wound healing
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批准号:nhmrc : 508097
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项目类别:NHMRC Project Grants
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资助金额:$18.76万
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财政年份:2008
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负责人:Prof Stuart Pitson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 508098
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项目类别:NHMRC Research Fellowships
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资助金额:$38.02万
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财政年份:2008
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负责人:Prof Stuart Pitson
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依托单位:
The molecular mechanisms regulating oncogenic signalling by sphingosine kinase 1 phosphorylation and localisation
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批准号:nhmrc : 453512
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项目类别:NHMRC Project Grants
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资助金额:$31.02万
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财政年份:2007
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负责人:Prof Stuart Pitson
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依托单位:
The molecular mechanism of sphingosine kinase activation
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批准号:nhmrc : 232905
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项目类别:NHMRC Project Grants
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资助金额:$29.51万
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财政年份:2003
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase activation and its downstream consequences
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批准号:nhmrc : 232910
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项目类别:Career Development Fellowships
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资助金额:$29.04万
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财政年份:2003
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负责人:Prof Stuart Pitson
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依托单位:
国内基金
海外基金
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批准号:82372275
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项目类别:面上项目
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批准年份:2023
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:赵培泉
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依托单位: