VG 70S-250SEQ HYBRID MASS SPECTROMETER

美国能源部建立了一个联合质谱仪。 加州大学环境科学与工程与化学 北卡罗来纳州教堂山。该机制的长期目标 是支持和促进生物医学的研究和教学 北卡罗来纳大学的光谱分析。这些目标将通过以下具体目标来实现 该设施：鼓励在健康领域使用质谱学- 通过与学生和教职员工的积极互动，促进相关科学的发展 通过讨论和实践提供质谱学方面的培训 体验；使用质谱学来回答对 NIH资助的研究的成功在标题下进行了更详细的讨论 《主要用户研究项目说明》。该设施将 提供鉴定和结构表征的能力 重要的生物分子，如核苷、寡核苷酸、多肽 和类固醇以及拟用作或测试的合成化合物 药物和生物模型。此外，还可以访问 高度灵活、最先进的仪器设备预计将作为 用于开发质谱学新应用的催化剂 当前用户和其他研究人员在网上提出的生物医学研究问题 校园里。 这项提议要求为购买VG提供部分资金支持 70S-250SEQ混合型质谱仪。这台质谱仪有 电子碰撞电离、化学电离、快原子能力- 轰击、碰撞激活、气相色谱、高分辨率 和精确的质量测量。该仪器将由美国国立卫生研究院资助 和其他生物、生物化学、 化学、环境科学与工程、医学与医学 北卡罗来纳大学教堂山分校化学专业。这个 化学与环境科学与工程系 化学公司已承诺为购买这台仪器提供30万美元 余额327 471.90美元将从其他来源申请。

A joint Mass Spectrometry Facility has been created by the Department of Environmental Sciences and Engineering and Chemistry at the University of North Carolina at Chapel Hill. The long-term objectives of the Facility are to support and promote biomedical research and teaching in mass spectrometry at UNC. These objectives will be met by the specific aims of the facility: to encourage the use of mass spectrometry in the health- allied sciences by active interactions with students and faculty; to provide training in mass spectrometry via discussions and hands-on experience; to use mass spectrometry to answer questions crucial to the success of NIH-funded research discussed in more detail under the heading "Description of Research Projects of Major Users". The Facility will provide the capability of identification and structural characterization of important biomolecules, such as nucleosides and oligonucleotides, peptides and steroids as well as synthetic compounds intended for use or testing as pharmaceuticals and biological models. In addition, accessibility to highly flexible, state-of-the-art instrumentation is expected to serve as a catalyst for development of novel applications of mass spectrometry to biomedical research problems by current users and other investigators on campus. This proposal requests funds for partial support of the purchase of a VG 70S-250SEQ Hybrid Mass Spectrometer. This mass spectrometer has the capabilities of electron impact ionization, chemical ionization, fast-atom- bombardment, collisional activation, gas chromatography, high-resolution and accurate-mass measurements. The instrument will be used by NIH-funded and other researchers in the Departments of Biology, biochemistry, Chemistry, Environmental Sciences and Engineering, Medicine and Medicinal Chemistry at the University of North Carolina at Chapel Hill. The Departments of Chemistry and Environmental Sciences and Engineering and Chemistry have committed $300,000 towards the purchase of this instrument with a balance of $327,471.90 to be sought from other sources.