IN-UTERO FETAL GROWTH PATTERNS IN RELATION TO OUTCOME AT BIRTH

该项目已扩大到包括两项相关的研究。 第一项研究分析了来自随机临床试验的数据。 由研究小组在怀孕期间进行的诊断超声使用 挪威特隆赫姆的挪威调查人员。分析的目的是 是使用纵向测量来检查胎儿的生长模式 在整个怀孕期间：(1)联合-底部高度；(2)体重增加 每次产前检查；(3)连续双顶径和腹径 超声波测量；(4)母体血红蛋白水平。 回归模型已适用于每一项的序列测量 母亲。对回归系数进行了相关分析。 不同的出生尺寸指标，如体重、冠跟长度、 体重指数和出生体重与胎龄的百分比。使用 协方差分析程序、附加因素(例如，香烟 吸烟、饮酒、孕妇孕前体重过低等)将会是 测试了它在改变宫内生长模式方面的重要性。 除了上述研究外，还有一项前瞻性研究，以确定 胎儿宫内发育迟缓或小于妊娠的危险因素 年龄出生，始于1984年，通过研究合同机制与 伯明翰的阿拉巴马大学和特隆赫姆大学， 挪威(与卑尔根大学和乌普萨拉大学合作)。这个 研究方案包括在17周前招募孕妇 怀孕了。那些登记参加这项研究的人将被仔细监测 在她们怀孕的剩余时间里。对称和不对称 胎儿宫内发育迟缓的形式将在产前和 在送货时。研究母亲所生的婴儿将接受后续检查 在生命的第一年，评估追赶增长和实现 早期发展里程碑。

The project has been expanded to encompass two related research studies. The first study has analyzed data derived from a randomized clinical trial of diagnostic ultrasound use during pregnancy conducted by the team of Norwegian investigators in Trondheim, Norway. The purpose of the analysis is to examine fetal growth patterns using longitudinal measurements throughout pregnancy of: (1) symphyseal-fundal heights; (2) weight gain at each prenatal visit; (3) serial biparietal and abdominal diameter measurements from ultrasound; and (4) maternal hemoglobin level. Regression models have been fit to the serial measurements for each mother. The coefficients of the regressions have been analyzed in relation to various indicators of birth size such as weight, crown-heel length, ponderal index, and birth weight-for-gestational age percentile. Using an analysis of covariance procedure, additional factors (e.g., cigarette smoking, alcohol intake, low maternal prepregnancy weight, etc.) will be tested for significance in modifying intrauterine growth patterns. In addition to the study described above, a prospective study to determine risk factors for intrauterine growth retardation, or small-for-gestational age birth, was begun in 1984 through the research contract mechanism with both the University of Alabama in Birmingham and University of Trondheim, Norway (in collaboration with the Universities of Bergen and Uppsala). The study protocol includes recruitment of pregnant women before 17 weeks gestation. Those enrolled in the study will be carefully monitored throughout the remainder of their pregnancy. Symmetric and asymmetric forms of intrauterine growth retardation will be assessed prenatally and at delivery. Infants born to the study mothers will have follow-up exams during the first year of life to assess catch-up growth and attainment of early developmental milestones.