EPILEPSY RESEARCH CENTER

这是一个多学科的研究项目，采用创新的分析方法 相关的神经生理学、生化和神经生物学的研究方法 癫痫的药理学方面。在面向临床的研究中， 临床和电信号的时间变异性和生物节律分析 癫痫活动随时间的变化在参数分析中检查治疗反应 根据癫痫的类别、药物水平、临床发作情况设计 发病率和癫痫样脑电活动。 设计和应用基于计算机的系统来改进脑电检测， 癫痫发作过程的表征和量化是一个主要方面 研究计划的设计和应用，以及 基于多微处理器的系统，用于经济有效地分析来自 长期的监测研究。 一种特殊设计的时间同步的多面体记录和录像带 系统被用来评估ACTH片段(4-9)在 婴幼儿痉挛的治疗及促肾上腺皮质激素是否有效 通过肾上腺轴或直接作用于大脑。 基础研究使用体外海马片技术来阐明 癫痫发生中的膜和突触机制及其作用机制 抗惊厥剂和镇静剂。癫痫发作对脑血管疾病的影响 脑微血管的神经源性控制和代谢交换 在戊四氮诱导的大鼠癫痫发作中进行检查，并 病理生理学机制参与阐述临床和 在一种新的全身性癫痫模型中研究了电发作。

This is a multidisciplinary research program, employing innovative analytical methods for the study of interrelated neurophysiological, biochemical, and pharmacological aspects of epilepsy. In the clinically oriented research, analysis of temporal variabilities and biorhythms of clinical and electrical epileptic activity over time examines therapeutic response in a parametric design as a function of epileptic class, drug levels, clinical seizure incidence, and epileptiform EEG activity. Design and application of computer-based systems to improve EEG detection, characterization, and quantification of the epileptic process is a major aspect of the research program, as is the design and application of multimicroprocessor-based systems for the cost-effective analysis of data from prolonged monitoring studies. A specically designed time-synchronized, polygraphic recording and video-tape system is utilized to evaluate the effectiveness of the ACTH fragment (4-9) in the treatment of infantile spasms and to determine if the effectiveness of ACTH is mediated via the adrenal axis or by direct action on the brain. Fundamental studies employ in vitro hippocampal-slice techniques to elucidate membrane and synaptic mechanisms in epileptogenesis and the mechanisms of action of anticonvulsant and convulsant agents. The influence of epileptic seizures on neurogenic control and metabolic exchange of the cerebral microvasculature is examined in pentylenetetrazol-induced seizures in the rat, and the pathophysiological mechanisms involved in the elaboration of clinical and electrical seizures are studied in a new generalized-epilepsy model.