INTERACTION BETWEEN POLYMERIZED HUMAN ALBUMIN AND HEPATITIS B VIRUS

建立了竞争抑制放射免疫分析法 用于定量分析与HBsAg结合的聚合的人 白蛋白。 基于这种分析，我们已经表明，特异性结合 对于戊二醛聚合白蛋白， 比其他程序聚合的人血白蛋白更强 例如加热、老化和Carabodiimide交联。 具体 聚合白蛋白的结合位点位于前S HBsAg基因产物。 抗体活性的测定程序 聚合白蛋白的方法。

A competitive inhibition radioimmunoassay has been developed for quantitative analysis of the HBsAg-binding polymerized human albumin. Based on this assay, we have shown that specific binding for glutaraldehyde polymerized albumin is at least 1,000 fold stronger than human albumin polymerized by other procedures such as heat, aging and carabodiimide cross-linking. The specific binding site for polymerized albumin is localized on the pre-S gene product of HBsAg. An assay procedure for antibody activity to polymerized albumin has been developed.