MOLECULAR GENETIC VARIATION IN NATURAL POPULATIONS

这个项目的主要重点是调查 突变、重组、遗传漂变和基因突变的相对作用 自然选择在形成遗传变异水平中的作用 在DNA水平上观察到。具体的实验寻找证据 在地理上的迁移和人口细分 中国汉族人ADH基因座DNA序列变异的分布 黑腹果蝇。有几个实验解决了 基本问题：分子的数量和质量是什么？ 种群遗传变异？要获得多个地点的一般答案 (白色，黄色到无色，g-6-Phd，叉形，朱红色，抑制器 叉子和叉子)在果蝇自然种群中 接受了调查。在这些和比较中有一个特定的问题 与其他物种的研究是巨大差异的结果 在分子上每千个碱基的交叉量 遗传变异。环境重金属的假说 已经选择复制金属硫蛋白基因 自然种群正在通过比较频率进行测试 在铅和铅含量差异较大的地区的这些变体中 镉污染。

The primary focus of this project is the investigation of the relative roles of mutation, recombination, genetic drift and natural selection in shaping the levels of genetic variation observed at the DNA level. Specific experiments look for evidence of migration and population subdivision in the geographic distribution of DNA sequence variation at the Adh locus in Drosophila melanogaster. Several experiments address the fundamental question: what is the quantity and quality of molecular population genetic variation? To obtain a general answer many loci (White, yellow to achete, g-6-phd, forked, vermilion, suppressor of forked and forked) in natural populations of Drosophila have been surveyed. A specific question in these and comparative studies with other species is the consequence of large differences in the amounts of crossing over per kilobase on the molecular genetic variation. The hypothesis that environmental heavy metals have selected for duplication of the metallothionein gene in natural populations is being tested by comparing the frequencies of these variants in locations with large differences in lead and cadmium pollution.