STUDIES IN THYROID DISEASE

本文探讨了甲状腺素结合球蛋白（TBG）偏低的原因。 非甲状腺疾病（NTI），当通过免疫放射测量 检测试剂盒。 我们发现不饱和游离脂肪酸 酸，几种非甾体抗炎药和 利尿剂，速尿，抑制甲状腺激素结合。 虽然 试剂盒可用于测试结合抑制，但不应 用于测量循环TBG浓度。 一种简化的低碘饮食是为门诊病人开发的， 甲状腺癌的I-131扫描和治疗。 碘摄入量 五个受试者的饮食是大约50杯一天，这 水平维持了四周。 所需的饮食仅 最少的指令，以可靠地遵循。 这种碘含量 摄入可增加甲状腺癌的放射性碘摄取。

The reason for the low serum thyroxine-binding globulin (TBG) in nonthyroid illness (NTI) when measured by an immunoradiometric assay kit was investigated. We found that unsaturated free fatty acids, several non-steroidal anti-inflammatory drugs and the diuretic, furosemide, inhibit thyroid hormone binding. Although the kit can be used to test for binding inhibition, it should not be used to measure the circulating TBG concentration. A simplified low iodine diet was developed for outpatient use prior to I-131 scanning and therapy in thyroid cancer. Iodine intake of five subjects on the diet was approximately 50 mug a day and this level was maintained for four weeks. The diet required only minimal instruction to be followed reliably. This level of iodine intake may increase radioiodine uptake in thyroid carcinomas.