MOLECULAR ANALYSIS OF THE OM MUTATOR IN DROSOPHILA ANANASSAE

果蝇D.安纳纳塞的特点是， 超变，减数分裂雄性交换和转座子，汤姆 在基因组的22个位点上产生显性遗传 眼形态突变，Om. 为了了解汤姆 元件特异性地跳转到Om位点， 元素导致眼睛发育缺陷， 特定位点Om（ID）已经被深入研究。 超过 20个突变已被分离和表征， 遗传学、细胞遗传学和DNA水平。 大规模克隆 OM（ID）研究中心已识别出大部分tom插入;但更多 克隆正在进行中。 额外的分子和遗传分析 在其他Om基因座和Som基因座上进行，其中许多 自发的显性抑制因子已经出现。

The Drosophila specie D. ananassae is characterized by hypermutability, meiotic male crossing over and a transposon, tom that specifically jumps to 22 sites in the genome cause dominant eye morphology mutations, Om. In order to understand how the tom element specifically jumps to Om loci and how the retrovirus-like element causes the defect in the development of the eye a particular locus, Om(ID), has been intensively studied. Over twenty mutations have been isolated and characterized at the genetic, cytogenetic and DNA level. Extensive cloning in the Om(ID) site has identified most of tom insertions; however more cloning is ongoing. Additional molecular and genetic analysis has been carried out on other Om loci and the Som locus where many spontaneous dominant suppressors have arisen.