COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS

免疫组织化学研究表明甘丙素(GAL)和 加压素(VP)共存于完全相同的细胞体中 视上核和大细胞侧室旁核 下丘脑外侧区的辅助细胞。脱水和 盐负荷，已知会导致VP的释放和枯竭 以及神经垂体中的催产素，也会引起明显的 大鼠脑后叶半乳糖样免疫反应减弱 脑下垂体。全身给药对短暂性脑缺血发作的影响 血压持续小幅升高，对心脏没有影响 费率。与VP相比，GAL的摩尔浓度是Vp的1000倍， 需要对血压产生类似的影响。高尔 对VP诱发的反应无调制作用。系统地 服用GAL后，利尿量略有增加，而 VP对利尿有完全和持续的抑制作用。盖尔·哈德 对VP的抗利尿作用无影响。的重要意义。 GAL和VP的共存尚待阐明。

Immunohistochemical studies have revealed that galanin (GAL) and vasopressin (VP) coexist in the very same cell bodies in the supraoptic and magnocellular paraventricular nuclei and the accessory cells of the lateral hypothalamic area. Dehydration and salt loading, which is known to cause release and depletion of VP and oxytocin from the neurohypophysis, also caused a marked reduction of GAL-like immunoreactivity in the posterior lobe of the pituitary. Effects of systemically administered GAL caused a short lasting small increase in blood pressure with no effect on heart rate. A thousand-fold molar concentration of GAL, compared to VP, was required to cause comparable effects on blood pressure. GAL had no modulatory effect on VP-induced response. Systemically administered GAL resulted in a mild increase in diuresis whereas VP caused complete and sustained inhibition of diuresis. GAL had no effect on VP-induced antidiuretic effects. The significance of the coexistence of GAL and VP remains to be elucidated.