MHC CLASS II ANTIGENS IN THE PATHOGENESIS OF INFLAMMATORY DISEASES

MHC II类抗原，人类的HLA-DR和小鼠的Ia， 膜结合糖蛋白是由主要的 组织相容性复合体 这些抗原的表达是 对启动和延续的巨大功能重要性 免疫反应。 在一些免疫病理条件下，HLA- DR抗原阴性细胞被刺激表达II类 抗原 在这些情况下，免疫作用已被假定 用于II类抗原表达。 在过去的一年里，我们已经确定了II类抗原是否 在某些疾病中表达，并评估其可能的 在自身免疫性和炎症性疾病中的作用。 初步研究 确定了眼前节和视网膜中的细胞 (rpe细胞）表达II类抗原 疾病 单克隆抗Ia抗体治疗减少了 临床疾病和MHC II类抗原的表达。 这些研究表明，MHC Ⅱ类抗原表达的局部 自身免疫性疾病提供的证据表明，激活这些 抗原可能有助于这些免疫发病机制， 疾病

MHC class II antigens, HLA-DR in the human and Ia in the mouse, are membrane bound glycoproteins that are encoded by genes of the major histocompatibility complex. Expression of these antigens is of great functional importance for the initiation and perpetuation of immune responses. In a number of immunopathologic conditions HLA- DR antigen negative cells are stimulated to express class II antigens. In these cases an immunologic role has been postulated for the class II antigen expression. During the past year, we have determined if class II antigens are expressed in certain diseases as well as evaluated their possible role in autoimmune and inflammatory diseases. Initial studies identified cells in the anterior segment and cells in the retina (rpe cell) which express class II antigens during inflammatory eye diseases. Treatment with monoclonal anti-Ia antibodies diminished the clinical disease and the expression of MHC class II antigens. These studies on MHC class II antigen expression in localized autoimmune diseases provide evidence that the activation of these antigens may contribute to the immunopathogenesis of these diseases.