TIME TRENDS IN THE INCIDENCE OF BILIARY ATRESIA

肝外胆道闭锁是一种肝脏疾病， 婴儿期，表现为肝外 胆管 据估计，每8000人中 每15000名活产婴儿中就有一例， 小儿肝移植手术指征 没有一个发病率数字是基于一个明确定义的 地缘政治区域;大多数估计的频率，这 条件是从转介中心。 一些调查人员 提出了这种情况的时空集群。 这个项目收集了出生证明和其他信息 在12岁以上出生的儿童中发生的所有病例 在俄亥俄州的几年。 确定了94例病例， 这相当于每10 000名新生儿0.5例。 案件将 与该州其他出生的婴儿进行比较， 发生率和聚集性。 一些潜在的风险因素 我们会检查的

Extrahepatic biliary atresia is a liver disease presenting in early infancy, manifested by progressive obliteration of the extrahepatic bile ducts. It has been estimated to occur in from one per 8000 to one per 15000 live births, and is the single most common indication for performance of liver transplantation in children. None of the incidence figures is based on a well defined geopolitical region; most estimates of the frequency of this condition are derived from referral centers. Some investigators have suggested a time-space clustering of this condition. This project has gathered birth certificates and other information on all cases occurring among children born over a period of 12 years in Ohio. Ninety-four (94) cases were identified, corresponding to a rate of 0.5 cases/10,000 births. Cases will be compared to the other births in the state for evidence of changes in incidence and clustering. A number of potential risk factors for the condition will be examined.