LOCAL CEREBRAL GLUCOSE METABOLISM IN MAN

这项研究是一项跨学科、跨部门的研究。 共同努力，使我们能够探索局部脑葡萄糖 代谢在人的大脑和它是如何改变在各种生理 和病理情况。 这样的探索现在是可能的 由于18F-氟脱氧葡萄糖方法的发展， 测量人的局部脑葡萄糖代谢。 文献中的大量数据表明， 功能活动、新陈代谢和血液流动。 因此，随着 由于特定的刺激而引起的大脑某个区域的功能活动 会增加局部代谢率和局部灌注。 因此，拟议的研究不仅将为我们提供重要的新的 关于局部脑葡萄糖代谢本身的信息，而且 可以用来绘制大脑中被激活的区域， 具体刺激。 要研究的生理刺激是视觉刺激 和认知任务。 此外，病理条件对 检查局部脑代谢和局部脑灌注。 这些疾病是中风、癫痫、阿尔茨海默病和脑肿瘤。

The proposed research is an interdisciplinary, intedepartmental collaborative effort to enable us to explore local cerebral glucose metabolism in the brain of man and how it is altered in various physiologic and pathologic situations. Such an exploration is now possible for the first time due to the development of the 18F-fluorodeoxyglucose method for the measurement of local cerebral glucose metabolism in man. There is extensive data in the literature suggesting a close link in the brain among functional activity, metabolism and blood flow. Thus, with an increase in functional activity in a region of the brain due to a specific stimulus one would expect an increase in the local metabolic rate and local perfusion. The proposed studies thus will not only provide us with important new information concerning local cerebral glucose metabolism per se, but also can be used to map the regions of the brain that are activated by a specific stimulus. The physiologic stimuli to be investigated are visual and cognitive tasks. In addition, the effects of pathologic conditions on local cerebral metabolism and local cerebral perfusion will be examined. These conditions are stroke, epilepsy, Alzheimer's disease, and brain tumor.