ULTRAHIGH PERFORMANCE MASS SPECTROMETER

这份提案是为了购买超高性能质量 光谱仪，主要由俄亥俄州立大学共享使用 教职员工持有NI.H.年度运营支持 1,987,972美元，用于现有条件下不可行的实验 校园内的质谱仪(见项目说明)。这个 首选的仪器是傅里叶变换离子回旋加速器 共振质谱仪，配置为：3特斯拉 超导螺线管磁体，差动泵浦双磁体- 电池、外电子源、阵列处理器、Nd/YAG激光器 (包括振荡器/放大器和倍频器)和 接口、气相色谱仪和接口。这台仪器 将在多个研究小组之间共享，用于应用 包括(见项目说明)：低挥发性化合物(所有 用户)、激光解吸/电离(所有用户)、超高质量 分辨率(FLOSS)，用于离子结构测定的MS/MS(全部 用户)、气相碱性和酸度(配色板)，以及 心脏药物及其制剂的定性和定量分析 代谢物(鲁宁，罗伯逊)。仪器将会是 以服务为基础运营，每个研究项目的固定用户 将对团队进行自我操作培训。仪器将会是 由OSU园区安装、维护、运营和更新 化学仪器中心(A.G.马歇尔，主任)。

This proposal is for purchase of an ultrahigh performance mass spectrometer for shared use primarily by Ohio State University faculty holding combined N.I.H. annual operating support of $1,987,972, for experiments that are not feasible with existing mass spectrometers on campus (see Project Description). The preferred instrument is a Fourier transform ion cyclotron resonance mass spectrometer, configured to include: 3 tesla superconducting solenoidal magnet, differentially pumped dual- cell, external electron source, array processor, Nd/YAG laser (including oscillator/amplifier and frequency doubler) and interface, and gas chromatograph and interface. The instrument will be shared among several research groups, for applications including (see Project Description): low-volatility compounds (all users), laser desorption/ionization (all users), ultrahigh mass resolution (Floss), MS/MS for ion structure determination (all users), gas-phase basicities and acidities (Paquette), and qualitative and quantitative analysis of heart drugs and their metabolites (Reuning, Robertson). The instrument will be operated on a service basis, and regular users from each research group will be trained for self-operation. The instrument will be installed maintained, operated, and updated by the OSU Campus Chemical Instrument Center (A.G. Marshall, Director).