ALSPAC and Adolescent Substance Use Trajectories: Consolidation of a UK research resource

英国青少年滥用和依赖物质的情况在欧洲名列前茅。物质使用，虽然通常在青春期开始，但是不同的，可能在不同的人之间遵循不同的模式或轨迹。这一点很重要，因为特定的药物使用轨迹可能有不同的原因，可能更有可能导致青少年和成人结果不佳。如果将青少年药物使用作为单一的平均衡量标准，可能会遗漏这些特征和模式。因此，对这一领域的研究需要确定药物使用轨迹的常见类型，以便测试和探索与其原因有关的具体研究问题，或谁可能受益或需要成为预防活动的目标。这还需要关于物质使用前的早期生活的详细信息，以及关于物质使用在青春期如何发展的信息。雅芳对13,000名儿童的父母和儿童纵向研究(ALSPAC)是世界上拥有此类信息的最大出生队列，参与者？自10岁起定期评估自我报告的物质使用情况(烟草、酒精、大麻和其他非法药物)。此外，在15岁和17岁时，通过头发和尿液筛查收集了物质使用的生物指标，并在3000名受试者中获得了全基因组扫描的信息。我们的目标是将收集到的关于物质使用和潜在风险因素的数据结合在一起，以创建一个可访问的研究资源。我们的目标是识别和提供青少年使用药物的不同轨迹；将自我报告的数据与毒理学证据进行比较和验证；创建自我报告的药物使用的可访问数据库，并确定在ALSPAC中收集的可能涉及增加或降低药物使用风险的所有关键措施；以及对有和没有不同药物使用轨迹的人的全基因组扫描进行初步比较，以确定用于进一步研究的潜在遗传位点。

Substance misuse and dependence among adolescents and young people in the UK is among the highest in Europe. Substance use, though typically initiated in adolescence, is heterogeneous and likely to follow different patterns or trajectories among different people. This matters because specific trajectories of substance use may have a different range of causes and maybe more likely to lead to poor adolescent and adult outcomes. These characteristics and patterns maybe missed if adolescent substance use is treated as a single average measure. Research, therefore, into this area needs to identify the common types of substance use trajectory in order then to test and explore specific research questions concerning their cause, or who may benefit or needs to be targeted by prevention activities. This also will require detailed information on early life, before substance use, as well as information on how substance use develops during adolescence. The Avon Longitudinal Study of Parents and Children (ALSPAC) of 13,000 children is the largest birth cohort with such information in the world, with participants? self-reported substance use (tobacco, alcohol, cannabis and other illicit drugs) assessed regularly since the age of ten. In addition, biological measures of substance use through hair and urine screens were collected at age 15 and 17, and information from a genomewide scan is available on 3000 subjects. We aim to bring the data collected on substance use and potential risk factors together in order to create an accessible research resource. We aim to identify and make available the different trajectories of adolescent substance use; compare and validate self-reported data with toxicological evidence; create an accessible database of self-reported substance use and identify all the key measures that have been collected in ALSPAC that may be involved in increasing or decreasing the risk of substance use; and conduct preliminary comparisons of whole genome scans of people with and without different substance use trajectories to identify potential genetic sites for further investigation.