Deregulation of ribosome signalling, synthesis and function during malignant transformation.

肿瘤进展的一个主要特征是加速细胞生长和蛋白质合成。此外，核糖体(蛋白质合成机制)的合成增加与恶性肿瘤有关，这表明它可能在癌症形成中发挥因果作用。为了支持这一点，核糖体生物发生和功能的特定抑制剂在抑制某些肿瘤的生长方面非常有效。本研究将探讨肿瘤形成过程中核糖体生物发生和功能失调的机制，并首次评估核糖体生物发生和功能的异常调节是否直接参与癌症的发生和发展。

A major feature of tumour progression is accelerated cell growth and protein synthesis. Moreover, increased synthesis of ribosomes (the protein synthetic machinery) is associated with malignancy suggesting that it may play a causal role in cancer formation. In support of this, specific inhibitors of both ribosome biogenesis and function are extremely effective in inhibiting the growth of some tumours. This study will examine the mechanisms of deregulation of ribosome biogenesis and function during cancer formation and assess for the first time whether aberrant regulation of ribosome biogenesis and function directly contributes to the initiation and-or progression of cancer.