STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的目的是研究 调节氧与血红蛋白的结合和氧的运输 到组织。 该项目还侧重于这些功能的方式， 会随着年龄的增长而改变 因此，我们研究了 参与血红蛋白的氧化。 氧化作用影响氧气 运输，因为它产生非功能性血红蛋白， 结合氧。 这些研究已经扩展到包括调查 整个红细胞和红细胞膜的稳定性， 以及膜中的其他结构功能关系。

The purpose of this project is to study the mechanisms involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. The project also focuses on ways in which these functions are impaired and change with age. We have therefore studied the mechanisms involved in the oxidation of hemoglobin. Oxidation affects oxygen transport because it produces nonfunctional hemoglobin, which no longer binds oxygen. These studies have been extended to include an investigation of the stability of the entire erythrocyte and the erythrocyte membrane as well as other structure function relationships in membranes.