MEDICINAL CHEMISTRY APPLIED TO PROBLEMS PROMINENT IN SENESCENCE

研究了与衰老有关的两个问题。在田野里 对儿茶酚胺的同系物的研究结果如下：(A) 一系列新的选择性破坏β-肾上腺素受体的化合物 开发了比以前更好的大约两个数量级的索引 可用的化合物。结果表明，新的系列将使 脑内β-肾上腺素受体的选择性操作将在 务实的态度。(B)一种能活化然后附着的化合物 永久使用β-肾上腺素能受体。对此的评价 复合体提示β-肾上腺素能受体具有内在的自我失活作用 容量，即在激活状态下不能卡住。(C)方向 开始了对多巴胺限制物的研究。在增溶剂领域 之前开发的化合物中的亲脂激素和药物， 对环糊精的亲水衍生物进行了深入的分析，并 大量准备，以支持两项临床评估研究。

Two problems which have relevance to aging have been studied. In the field of congeners of catecholamines the following results were obtained: (A) A new series of compounds which selectively destroy beta-adrenoceptors was developed which has indexes about two orders better than previously available compounds. The results suggest that new series will enable selective manipulation of beta-adrenoceptors in brain to be performed in a practical manner. (B) A compound which activates and then attaches itself permanently to beta-adrenoceptors was prepared. Evaluation of this compound indicates that beta-adrenoceptor has intrinsic self-deactivation capacity, i.e. cannot be jammed in activated state. (C) Orientation studies of dopamine confiners were initiated. In the field of solubilizers of lipophilic hormones and drugs the previously developed compounds, hydrophilic derivatives of cyclodextrins, were analyzed thoroughly and prepared in quantity to support two clinical evaluation studies.