ANALYSIS OF SUDDEN INFANT DEATH SYNDROME (SIDS) RISK FACTORS

NICHD合作SIDS研究旨在识别 可以区分SIDS婴儿和非SIDS婴儿的危险因素。 本研究设计为多中心、人群为基础的病例对照研究 840例SIDS病例（800例单胎和40例多胎SIDS 例）根据共同尸检协议确定。 有1600人 匹配的存活单胎对照婴儿和40例共多胎对照 婴儿被招募到研究中。 这是最大的详细 对小岛屿发展中国家进行的流行病学研究。 数据收集于 从1978年10月到12月，15个月内死亡的婴儿， 1979. 每一个婴儿的死亡都是按照一个常见的 专门为研究制定的尸检方案。 二十六 保存不同的组织切片， 由三名小岛屿发展中国家病理学专家组成的小组。 根据机构间协定 与武装部队病理学研究所（AFIP）合作， 为编制《小岛屿发展中国家历史地图集》提供的资金， “学习集”在法医学专业实践教学中的应用 病理学家或病理学学生。 在另一项小岛屿发展中国家风险因素研究中， 被用来检查潜在的异常发展， 神经生理和心肺控制机制在第一 三个月的生活。 研究材料由计算机数据组成 来自三个婴儿的长期电生理记录集， 早期的小岛屿发展中国家研究。 将在以下方面进行比较： 以下婴儿群体：SIDS婴儿的后续兄弟姐妹， “差点”的婴儿、双胞胎、匹配的对照组和后来死于 婴儿猝死综合症。

The NICHD Cooperative SIDS Study was designed to enable identification of risk factors which could differentiate SIDS infants from non-SIDS infants. The design is that of a multicenter, population-based, case-control study with a sample of 840 SIDS cases (800 singleton and 40 multiple birth SIDS cases) ascertained under a common necropsy protocol. There were 1,600 matched living singleton control infants and 40 co-multiple birth control infants recruited into the study. It is the largest detailed epidemiological study of SIDS ever undertaken. Data were collected for babies who died over a 15-month period from October, 1978 through December, 1979. Every infant death was autopsied in accordance with a common necropsy protocol developed specifically for the study. Twenty-six different slides of tissues were preserved for detailed examination by a panel of three SIDS pathology experts. Under an Inter Agency Agreement with the Armed Forces Institute of Pathology (AFIP), technical support is being provided for the preparation of a SIDS Histopathology Atlas and "study sets" to be used for the education of practicing forensic pathologists or pathology students. In another SIDS risk factor study, techniques of time series analysis are being used to examine potential abnormalities in the development of neuro-physiological and cardio-respiratory control mechanisms in the first three months of life. The study materials consist of computerized data sets from long-term electrophysiological recordngs of infants from three earlier SIDS research studies. Comparisons will be made among the following groups of infants: subsequent siblings of SIDS infants, "near-miss" infants, twins, matched controls, and infants who later died of SIDS.